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Pharma 11 Twin-screw Extruder

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The Thermo Scientific™ Pharma 11 Twin-Screw Extruder is designed to deliver material- and labor-effective extrusion, offering a cost-effective solution for the development and production of pharmaceutical compounds. With a focus on efficiency, this extruder requires only a small amount of active pharmaceutical ingredient (API) and operates at throughput levels as low as 20g/h.

Key Features:

  1. Small Material Quantities: Enables faster and cost-effective development by using smaller material quantities.

  2. Versatile Applications: Easily converts from hot melt extrusion (HME) to twin-screw granulation (TSG) applications, providing flexibility in processing.

  3. Throughput Ranges: Operates at throughput ranges from 20g/h up to 2.5kg/h, accommodating various production scales.

  4. Scalable Design: The parallel 11mm twin screws and compact design are fully scalable with Thermo Scientific stand-alone pharmaceutical compounding systems, allowing for process relevant results and small-scale production.

  5. Geometric Scalability: Screw elements and barrel design scale geometrically across all Thermo Scientific Pharma Extruders, facilitating easy process scale-up.

  6. User-Friendly Operation: Features an easy-to-operate, intuitive touch screen with integrated feeder control for enhanced user experience.

  7. Compact Design: Maximize lab space with a small footprint machine, suitable for glove box or isolator applications, and a removable touch screen for added flexibility.

  8. Removable Parts: All material contact parts are easily removable, simplifying cleaning and maintenance.

  9. Documentation and PAT: Enables documentation of extrusion parameters and is suitable for process analytical technology (PAT) for enhanced process control.

  10. GMP-Compliant: GMP-compliant with full validation available, including Factory Acceptance Test (FAT), Site Acceptance Test (SAT), Installation Qualification/Operational Qualification (IQ/OQ).

The Thermo Scientific™ Pharma 11 Twin-Screw Extruder is a versatile and efficient solution for pharmaceutical extrusion, offering flexibility, scalability, and ease of use for a range of applications from development to small-scale production.


Chris Bradburn


Technical specification

The Pharma 11 Twin-screw Extruder Video


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