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Pharma 24 Twin-screw Extruder

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The Thermo Scientific™ Pharma 24 Twin-Screw Extruder, equipped with Hot Melt Extrusion (HME) and Twin-Screw Granulation (TSG) Application Sets, stands as an ideal solution for continuous processing in the pharmaceutical industry. Tailored for research, development, or production, this extruder offers several advantages, including reduced cleanroom area, consistent and controllable processing, minimized product changeover time, on-demand production, reduced scale-up risk, and reliable cleaning. It is also suitable for Process Analytical Technology (PAT), allowing for effective process monitoring.

Key Features:

  1. Small Footprint: Occupies minimal space in clean rooms, optimizing cleanroom efficiency and layout.

  2. Continuous Operation: Enables continuous processing, consuming fewer utilities compared to traditional batch processes.

  3. High Free Volume Screw Design: The extruder features a high free volume screw design, enhancing its processing capabilities.

  4. Small Process Inventory: Minimizes the process inventory, contributing to efficient and controlled operations.

  5. Lower Ingredient Consumption: Reduces ingredient consumption, thereby minimizing handling and operator exposure.

  6. Segmented Screws and Barrel: The segmented screws and barrel design allow for flexibility in processing and ease of maintenance.

  7. Removable Screws and Liners: Facilitates easy removal of screws and liners, streamlining cleaning and maintenance processes.

  8. PAT Compatibility: Supports Process Analytical Technology (PAT) applications, allowing for the monitoring of critical process parameters to assure required product quality. The Pharma 24 Extruder can be used with a range of PAT instruments such as Thermo Scientific™ FT-NIR system.

The Thermo Scientific™ Pharma 24 Twin-Screw Extruder is a versatile and efficient solution for pharmaceutical continuous processing, offering a small footprint, reduced cleanroom requirements, and compatibility with PAT for enhanced quality control. Whether in research, development, or production, this extruder is designed to meet the evolving needs of the pharmaceutical industry.


Chris Bradburn


Technical specification


We offer a full range of GMP compliant ancillaries which are matched to the extruder performance. This downstream equipment can be integrated into the extruder control system.

For TSG configurations: available ancillaries include volumetric or gravimetric dosing feeders and liquid injection pumps.

In addition, self-contained units of either configuration can be operated with recirculating chillers to reduce water consumption.

TSG configuration recommended for:

  • Wet granulation
  • Dry/melt granulation

For HME configurations: available ancillaries include volumetric or gravimetric dosing feeders, air cooled conveyors for product cooling, strand and face-cut pelletizers to make pellets, or chill roll/flaker units for rapid product cooling and flaking. 

HME configuration recommended for:

  • Solubility enhancement
  • Modified release
  • Co-extrusion
  • Drug delivery systems
  • Biomedical products

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